Pro-inflammatory Cytokines for Evaluation of the Diagnostic Performance for the Urinary Bladder Cancer
نویسنده
چکیده
Objective: This study designed to evaluate the role of serum cytokines marker in the diagnosis and prognosis of urinary bladder cancer. Patients and Methods: The study was conducted in Basrah Hospitals, Iraq between September 2011 till July 2012. Blood samples were collected from 45 patients (mean age 63.52 ± 10.96 years) with urinary bladder cancer and from 45 apparently healthy control groups with (mean 46.41 ± 8.23 years). ELISA test was used for detection of serum TNF-α, IFN-Υ, IL-8 and IL-12. TNF-α revealed higher serum level in patients (20.8 ± 27.22) pg/ml in comparison with control group (1.189 ±26.51) pg/ml (p<0.5). A significantly higher serum INF-Υ of patients (5.272.41) pg/ml in comparison with control group (4.01±1.1) pg/ml (p<0.5). Similar a significantly increase serum level of IL-8 in patients (51.4938.43) pg/ml in comparison with control group (36.55 ± 15.28 ) pg/ml(p<0.5). IL-12 revealed a significantly higher serum level in patients (4.29 3.95) ng/L than that of the control control group (1.09±2.14) ng/L (p<0.5). Conclusion: Serum cytokines are important diagnostic and prognostic tools for urinary bladder cancer and good predictor for disease.
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